We present current knowledge on the clinical diagnosis, histopathological classification, molecular data, and management strategies in Non-functioning pituitary adenomas
2021
Key concepts
Scholarcy highlights
- Non-functioning pituitary adenomas are clinically silent tumors and the second most common pituitary adenoma
- We present current knowledge on the clinical diagnosis, histopathological classification, molecular data, and management strategies in NFPA
- NFPA is a heterogeneous group of tumors, in respect to their origin and clinical course
- Research on pathology and molecular biology have advanced our knowledge of NFPA pathogenesis
- The understanding of the mechanisms involved in the genesis and progression of NFPA is crucial for the identification and development of directed treatments with higher chances of response
- NFPA of corticotrophic origin seemed to be more aggressive, but a recent systematic review showed that they do not have a higher risk of recurrence compared to other NFPA subtypes
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