Current opinion on the diagnosis and management of non-functioning pituitary adenomas

We present current knowledge on the clinical diagnosis, histopathological classification, molecular data, and management strategies in Non-functioning pituitary adenomas

Elisa B. Lamback; Luiz Eduardo Wildemberg; Mônica R. Gadelha

2021

Scholarcy highlights

  • Non-functioning pituitary adenomas are clinically silent tumors and the second most common pituitary adenoma
  • We present current knowledge on the clinical diagnosis, histopathological classification, molecular data, and management strategies in NFPA
  • NFPA is a heterogeneous group of tumors, in respect to their origin and clinical course
  • Research on pathology and molecular biology have advanced our knowledge of NFPA pathogenesis
  • The understanding of the mechanisms involved in the genesis and progression of NFPA is crucial for the identification and development of directed treatments with higher chances of response
  • NFPA of corticotrophic origin seemed to be more aggressive, but a recent systematic review showed that they do not have a higher risk of recurrence compared to other NFPA subtypes
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