Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics

The results showed that these nanoparticles in combination with NIR exposition caused 82.60% tumour volume reduction compared with free photoporphyrin

Juan L. Paris

2019

Scholarcy highlights

  • Nanoparticle use for cancer treatment has attracted significant attention, and several products are already approved for clinical use
  • Nu Areas covered: The available information about the in vitro and in vivo biocompatibility, as well as the biodegradability of the following nanoparticles is presented and a discussed: superparamagnetic iron oxide nanoparticles, gold nanoparticles, graphene and mesoporous nanoparticles made of silicon or silicon oxide
  • Ted We believe that among the materials that can be highlighted, especial attention can be directed upon superparamagnetic iron oxide nanoparticles, gold nanoparticles, p graphene and mesoporous nanoparticles made of silicon or silicon oxide
  • Ivanov et al showed that Mesoporous silicon nanoparticles presented a good biocompatibility profile in vivo after intravenous injection, with a significantly reduced number of foreign body-type granulomas compared to animals injected with mesoporous silica nanoparticles
  • Nanoparticle shape has s been shown to affect biodistribution of orally-administered Mesoporous silica nanoparticles, with particles u with larger aspect ratios presenting decreased biodegradation, systemic absorption and n especially, reduced liver distribution and excretion in urine. a 6.1 Protocells M As it has mentioned along this section, mesoporous silica is an excellent material for d drug delivery due to its extremely high loading capacity and excellent biocompatibility, and the possibility of developing a wide variety of stimuli-responsive nano-DDS
  • R Mesoporous silica nanoparticles here did not cause significant toxicity in vivo, some biliary excretion and c glomerular filtration dysfunction could have been induced. Nanoparticle shape has s been shown to affect biodistribution of orally-administered MSNs, with particles u with larger aspect ratios presenting decreased biodegradation, systemic absorption and n especially, reduced liver distribution and excretion in urine. a 6.1 Protocells M As it has mentioned along this section, mesoporous silica is an excellent material for d drug delivery due to its extremely high loading capacity and excellent biocompatibility, and the possibility of developing a wide variety of stimuli-responsive nano-DDS

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