New insights into human prefrontal cortex aging with a lipidomics approach

We explore the role of lipids in Human prefrontal cortex aging

Mariona Jové; Natalia Mota-Martorell; Pascual Torres; Manuel Portero-Otin; Isidre Ferrer; Reinald Pamplona


Scholarcy highlights

  • Human prefrontal cortex is a recent evolutionarily developed brain region involved in cognitive functions
  • We explore the role of lipids in Human prefrontal cortex aging
  • It is suggested that the dysfunction of key cellular processes secondarily to the damage of lipid membrane underlies the cognitive decline of hPFC during aging
  • During hPFC aging, there are relatively minor changes in lipid profile affecting cholesterol content, which shows a decrease in abundance, as well as in GP and SP, that affects specific lipid molecular species containing AA and DHA
  • Lipids represent up to 50% of the dry matter of the human brain, and present the greatest structural and functional diversity of molecular species in the human body
  • This paper was funded by the Institute of Health Carlos III to M.P-O., I.F., and RP, the Spanish Ministry of Science, Innovation, and Universities to R.P., and the Generalitat of Catalonia: Agency for Management of University and Research Grants to R.P
  • The generation and accumulation of lipoxidation-derived molecular damage is a central mechanism of age-related functional decline in Human prefrontal cortex

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