Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats

Context: Overconsumption of paracetamol and diclofenac have been reported to induce neurotoxicity and endocrine disruption

Tarek K. Motawi; Samia A. Ahmed; Noha A. El-Boghdady; Nadia S. Metwally; Noha N. Nasr

2019

Scholarcy highlights

  • Context: Overconsumption of paracetamol and diclofenac have been reported to induce neurotoxicity and endocrine disruption
  • The current study was designed to explore the protective potential of betanin against PAR and DF inducing neurotoxicity and endocrine disruption in a rat model
  • Material and Methods: Forty rats were divided into five groups: group I served as control, group II received PAR, group III received PAR plus betanin, group IV received DF and group V received DF plus betanin orally for 28 consecutive days
  • Sex hormone, neurotransmitters, paraoxonase-1, hemeoxygenase-1 and nuclear factor-2 were measured by ELISA
  • A marked reduction in thyroid axis hormones, brain neurotransmitters and serum testosterone as well as enhanced oxidative stress and brain DNA damage accompanied by drastic changes in the brain histopathological picture were recorded in the challenged PAR and DF groups
  • The study suggests betanin of potential protective effects against neurotoxicity and endocrine disruption induced by PAR and DF overconsumption

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