Enhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system in vivo

Based on our previous report of a novel delivery system for curcumin using functionalized single-walled carbon nanotubes by phosphatidylcholine and polyvinylpyrrolidone, we further evaluated SWCNT-Cur’s performance in vivo and characteristics in vitro

Haixia Li; Nan Zhang; Yongwei Hao; Yali Wang; Shasha Jia; Hongling Zhang


Scholarcy highlights

  • Curcumin, a hydrophobic polyphenol compound extracted from the rhizome of Curcuma longa L., has exhibited extensive anti-tumor potential in a wide range of cancer, such as breast, colon, colorectal, pancreatic, prostate, esophageal, head and neck cancers, endometrial carcinoma, and glioblastoma multiforme
  • Nanoparticles consisted of Cur and functionalized single-walled carbon nanotubes, firstly prepared by us, induced a significantly higher growth inhibition compared to native Cur and irradiated SWCNT in PC-3 cancer cells, and the inhibitory effect was further significantly enhanced by laser irradiation
  • Solvent residue is negligible in SWCNT-Cur formulation
  • The strong characteristic peaks at 1600, 1505, and 1426 cmÀ1, were maintained but became weaker in SWCNT-Cur, suggesting the conjugation strength of À C 1⁄4 C À was reduced due to forming intermolecular hydrogen bonds between Cur and carrier
  • As for the tumor tissues, control saline group with and without laser showed vigorous growth, tight arrangement, large body and intact shape, while cell necrosis, cell lysis, and cell fragment to a certain extent occurred in all the treatment groups, especially SWCNT-Cur groups, in accordance with inhibition of tumor growth
  • Cur and its laser groups showed certain inhibitory effect compared to the respective saline group, but there was no significant difference between them, indicating that laser did not enhances the antitumor activity of native Cur
  • The results showed that the obvious toxicity and adverse effects were hardly observed in SWCNT-Cur formulation and content of methanol is far less than the pharmacopeia requirements, suggested from the result of Gas Chromatography chromatogram and HE staining of heart, liver, spleen, lung, and kidney of mice
  • The mechanism underlying this effect may include three aspects: single-walled carbon nanotubes-Cur enhances the delivery of Cur into tumor cells by enhancing cellular uptake

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