Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress

The results showed that DJ-1 and its mutants were associated with Hsp70, CHIP and mtHsp70/Grp75, a mitochondria-resident Hsp70, and that L166P and M26I mutants found in Parkinson's disease patients were strongly associated with Hsp70 and CHIP compared to wild-type and other DJ-1 mutants

Hong Mei Li; Takeshi Niki; Takahiro Taira; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga

2005

Scholarcy highlights

  • DJ-1 is a novel oncogene and causative gene for familial form of the Parkinson's disease
  • DJ-1 has been shown to play a role in anti-oxidative stress by eliminating reactive oxygen species
  • The onset of PD is thought to be caused by oxidative stress and mitochondrial injury, which leads to protein aggregation that results in neuronal cell death
  • The results showed that DJ-1 and its mutants were associated with Hsp70, CHIP and mtHsp70/Grp75, a mitochondria-resident Hsp70, and that L166P and M26I mutants found in PD patients were strongly associated with Hsp70 and CHIP compared to wild-type and other DJ-1 mutants
  • These results suggest that translocation of DJ-1 to mitochondria after oxidative stress is carried out in association with chaperones

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