Implications of Research on Assays to Characterize Thyroid Toxicants

Many aspects of thyroid endocrinology are very well conserved across vertebrate taxa

R. Thomas Zoeller; Shirlee W. Tan

2007

Scholarcy highlights

  • Many aspects of thyroid endocrinology are very well conserved across vertebrate taxa
  • The system by which the hormone is delived from the thyroid gland to target cells, including transport and regulation within the hypothalamic-pituitary-thyroid axis, and the proteins that regulate the different components of this delivery system appear to be highly conserved across the vertebrates
  • The goal of this chapter is to provide a brief synopsis of the literature supporting existing screening and testing strategies in different vertebrate taxa, and to provide insight into the strengths, weaknesses, and likely changes over time
  • It was determined during this review that, because of the complexity of the thyroid system, it is unlikely that current in vitro assays for thyroid toxicity will be able to sufficiently replace in vivo assays for thyroid toxicants
  • Specific in vitro assays were identified for development, including the thyroid receptor binding and activation assays, and in vitro assays to evaluate thyroid hormone action
  • It is our hope that this series of thyroid articles will provide regulators and research scientists the information needed for each individual to identify the assays and endpoints most suited for their specific purposes

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