A Review of Carbon Nanotube Toxicity and Assessment of Potential Occupational and Environmental Health Risks

Because a few animals died of suffocation in our pilot study, in our core study we reduced the volume of the dose to 50 μl/mouse and modified the instillation technique by adopting the intratracheal fast instillation of Sabaitis et al

Chiu-wing Lam

2006

Scholarcy highlights

  • 2. Study of Several Single-Wall Carbon Nanotube Products in Mice by Lam et al For several years, National Aeronautics and Space Administration has had a facility that makes single-wall CNTs using the laser process developed by Rice University
  • Granulomas were less prominent but were still observed in the mice treated with the low dose of HiPco-synthesized carbon nanotubes; they were not seen in the groups treated with the low dose of graphite arcderived CNTs that contain lower content of single-wall CNTs
  • CNTs are capable of inducing inflammation, epithelioid granulomas, fibrosis, and biochemical toxicity changes in the lungs that might impair pulmonary functions
  • Even though ITI and modifications of this technique are common routes of administration used to assess the toxicity of dust in the lungs, it is imperative that inhalation toxicity studies be conducted to demonstrate whether CNT particles can reach the lung to produce the lung lesions seen in the ITI studies
  • Unless and until unequivocal data from inhalation studies can show that CNTs are devoid of toxicity, it is prudent to presume that prolonged occupational exposure to airborne fine CNT particulate matter could produce serious lesions in the lungs similar to those seen in animals
  • If airborne fine CNT particles are present in the workplace, strategies to minimize human exposures must be implemented, as recommended by Lam et al

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