Increased Total Heart Rate Variability and Enhanced Cardiac Vagal Autonomic Activity in Healthy Humans with Sinus Bradycardia

Sinus bradycardia can be defined as a sinus rhythm with a resting heart rate of 60 beats per minute or less

Craig S. Mclachlan; Ryan Ocsan; Ian Spence; Brett Hambly; Slade Matthews; Lexin Wang; Herbert F. Jelinek

2017

Scholarcy highlights

  • Sinus bradycardia can be defined as a sinus rhythm with a resting heart rate of 60 beats per minute or less
  • It is assumed that the vagal system is contributory toward sinus bradycardia, actual data relating to cardiac autonomic indices of asymptomatic patients with resting heart rates of Ͻ60 bpm are lacking
  • It is difficult to interpret if sympathetic drive is changed using time domain analysis, nonlinear analysis measures of heart rate variability revealed no significant sympathetic differences between subjects with sinus bradycardia and normal sinus rate
  • Bradycardia is associated with increased total power, as measured in the frequency domain
  • There were no significant differences in sympathetic frequency domain indices between the two groups
  • It has been shown that decreased HRV is associated with advancing age, which carries an increased risk of cardiac-related events in clinically disease-free patients ; this is not likely to be the case in aging populations with reduced HR
  • In an aging population, a slow heart rate is likely to confer cardioprotective benefits due to an associated increase in parasympathetic autonomic tone and an associated increase in total heart rate variability

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