Preparation and evaluation of niosome gel containing acyclovir for enhanced dermal deposition

Niosomes suggest a versatile vesicle delivery system with possible transport of drugs via topical route for skin delivery

Shery Jacob

2016

Scholarcy highlights

  • Niosomes suggest a versatile vesicle delivery system with possible transport of drugs via topical route for skin delivery
  • Niosome formulations were formulated by coacervation phase separation technique with different ratios
  • the acyclovir release from niosomes was strongly influenced by cholesterol
  • Ex vivo studies using formulation for drug deposition indicate greater amount of niosome being diffused into the skin layers
  • were analog to the profiles observed with ex vivo deposition studies
  • Comparison of kinetic data of acyclovir in the stratum corneum and plasma signifies that the niosome formulation forms a depot in the epidermis or dermis region
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