The Effect of Tapering the Optical Fiber on Evanescent Wave Measurements

Optical biosensors are analytical tools employed in environmental, biotechnology and clinical fields

Lisa C. Shriver-lake

2011

Scholarcy highlights

  • Optical biosensors are analytical tools employed in environmental, biotechnology and clinical fields
  • Silica fibers were tapered into two geometries: step and continuous tapers
  • To determine the effect of tapering on detection levels, a fluoroimmunoassay was performed on fibers with nontapered, step-tapered and continuously tapered geometries
  • Solutions containing a fluorescent analyte were circulated over an antibody-coated fiber and the fluoresence signal measured The minimum detection limit for fibers with 10 cm sensing region was 1.56 nM, 0.31 nM and 0.16 nM for nontapered, step-tapered and continuously tapered fibers, respectively
  • Continuous tapering of the sensing region of an optical fiber offered a 10-fold increase in the sensitivity of the optical biosensor
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