Detection of pharmaceutical contaminations of river, pond, and tap water from Cologne (Germany) and surroundings

This review critically evaluates the performance of sustainable green nanoadsorbent for the remediation of pharmaceutical pollutants from water

Ulrich Jux; Rainer M. Baginski; Hans-Günter Arnold; Martin Krönke; Peter N. Seng

2005

Scholarcy highlights

  • A method for the simultaneous determination of polar pharmaceutical compounds in water is presented
  • Samples from 27 rivers and ponds were investigated for contents of Gemfibrocil, a lipid blood regulating compound, Clofibric acid, a metabolite of lipid regulating compounds, antirheumatics and Sarkosin-N-(phenylsulfonyl), a metabolite of a corrosion inhibiting agent
  • In addition water samples were investigated for some main metabolites of Ibuprofen, 2-propionic acid and 2-propionic acid, which are excreted after oral intake
  • For gas chromatographic analysis the drugs were converted into their methyl-derivatives by “on column” reaction with TMSH, TMAH and “pre column” with diazomethane
  • The detection limits with TMSH were in the same range or lower than those with diazomethane or TMAH
  • After 18 days of batch incubation, diclofenac was removed up to 40%, this rate remained stable till the end of the experiment, while 4′-hydroxydiclofenac was completely degraded within nine days
  • Since further information is need to assess whether diclofenac should be included as substance of priority in the EU water framework directive, we investigated the impact of this analgesic on the embryonic development of brown trout from fertilized egg until the end of sac-fry stage and studied effects in juvenile fish six months post hatch
  • None of the pharmaceuticals investigated were present in 8 drinking water samples from Cologne and surroundings

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