Mitotic Phosphorylation of Dynamin-related GTPase Drp1 Participates in Mitochondrial Fission

These results suggest that phosphorylation of Drp1 on Ser-585 promotes mitochondrial fission in mitotic cells

Naoko Taguchi; Naotada Ishihara; Akihiro Jofuku; Toshihiko Oka; Katsuyoshi Mihara

2007

Scholarcy highlights

  • APRIL 13, 2007 VOLUME 282 NUMBER 15 fusion proteins are crucial for neuronal development, because Mfn2 and OPA1 are causal gene products of neuropathy, such as Charcot Marie tooth neuropathy type 2A and dominant optic atrophy type I, respectively
  • Mitochondrial Dynamics in Mitotic HeLa Cells—Mitochondrial morphology is maintained under dynamic movement with a balance between fusion and fission
  • Mitochondrial Fragmentation in Mitotic Cells Depends on Drp1— we focused on the function of the mitochondrial fission factor Drp1 in mitotic mitochondrial fragmentation
  • Organelles are inherited to daughter cells beyond dynamic changes of the membrane structures
  • Drp1 was phosphorylated at Ser-585 by Cdk1/cyclin B, which stimulated the mitochondrial fission in mitosis
  • We concluded that mitochondrial morphology is regulated by Drp1-dependent mitochondrial fission in mitotic cells
  • It should be noted that we and others have previously demonstrated that treatment of cultured cells with nocodazole does not induce mitochondrial fragmentation , suggesting that mitochondrial fragmentation in the mitotic phase is independent of disassembly of cytoplasmic microtubules

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