Melanocortin 1 Receptor Regulates Melanoma Cell Migration by Controlling Syndecan-2 Expression

Using highly motile melanoma cells, we found that the expression level of melanocortin 1 receptor was associated with the extent of migration of mouse melanoma cells, suggesting that MC1R plays a functional role in controlling this migration

Heesung Chung

2012

Scholarcy highlights

  • The melanocortin 1 receptor is known to regulate inflammation
  • melanocortin 1 receptor expression enhanced the synthesis of syndecan-2, a cell surface heparan sulfate proteoglycan known to be involved in melanoma cell migration
  • MC1R Regulates Melanoma Cell Migration—To explore the role played by MC1R in melanoma cell migration, we investigated whether the MC1R expression level affected the extent of such migration
  • MC1R is well known to play a role in regulation of melanin synthesis by melanocytes and melanoma cells
  • MC1R is located on the cell surface, transducing signals from extracellular functional ligands including ␣-MSH, adrenocorticotropic hormone, and Agouti signal protein
  • Elevated MC1R expression was associated with a rise in the extent of melanoma cell migration, whereas the opposite was true when MC1R expression was suppressed using siRNAs
  • melanocortin 1 receptor inhibits p38 activation, resulting in increased syndecan-2 expression and a subsequent enhancement in cell migration

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