Role of Peroxiredoxins in Regulating Intracellular Hydrogen Peroxide and Hydrogen Peroxide-induced Apoptosis in Thyroid Cells

These results suggest that Prx I and Prx II are involved in the removal of H2O2 in thyroid cells and can protect these cells from undergoing apoptosis

Ho Kim; Tae-Hoon Lee; Eun Shin Park; Jae Mi Suh; Soo Jung Park; Hyo Kyun Chung; O-Yu Kwon; Young Kun Kim; Heung Kyu Ro; Minho Shong

2002

Scholarcy highlights

  • Peroxiredoxins play an important role in regulating cellular differentiation and proliferation in several types of mammalian cells
  • These results suggest that Prx I and Prx II are involved in the removal of H2O2 in thyroid cells and can protect these cells from undergoing apoptosis
  • This study provides evidence for two significant conclusions: 1) Prx I and Prx II are involved in eliminating H2O2 produced by thyroid cells in physiological response to TSH, and 2) Prx I and Prx II protect thyroid cells from H2O2-induced apoptosis
  • This report shows that Prx I and Prx II are constitutively expressed in many rat tissues, including the thyroid gland and in rat thyroid FRTL-5 cells
  • Prx I is up-regulated by TSH in these cells. These results suggest that Prx proteins are involved in regulating intracellular H2O2 levels; for example, TSH-induced Prx I expression may be a mechanism for controlling the H2O2 generated in response to TSH
  • It is possible that TSH-induced Prx I expression is a response to the increase in H2O2 level resulting from TSH-stimulation
  • ). This study demonstrates that exposure of FRTL-5 cells to MMI enhances expression of Prx I, suggesting that MMI-mediated radical scavenging may depend on its ability to stimulate expression of Prx I

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