Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

These results demonstrate that debundled single-walled carbon nanotubes are highcontrast near-infrared fluorophores that can be sensitively and selectively tracked in mammalian tissues using optical methods

P. Cherukuri; C. J. Gannon; T. K. Leeuw; H. K. Schmidt; R. E. Smalley; S. A. Curley; R. B. Weisman

2006

Scholarcy highlights

  • S ingle-walled carbon nanotubes are an important class of artificial nanomaterials with remarkable mechanical, thermal, electronic, and optical properties
  • After excitation with visible light, each type of semiconducting SWNT fluoresces at a near-infrared wavelength between Ϸ900 and 1,600 nm that is characteristic of its specific structure
  • Proper dispersion of the resulting sample was confirmed by its strong near-IR fluorescence, which arises from individual but not from aggregated SWNTs
  • Four normal New Zealand rabbits were injected with a 7.5-ml bolus of this SWNT suspension through implanted jugular vein catheters
  • Rabbits were killed 24 h after SWNT injection, and their organs and tissue samples were harvested for histopathology and near-IR fluorescence imaging
  • Unlike the findings described here for pristine nanotubes, it was reported that i.v. administration of the functionalized SWNTs in mice led to efficient uptake and clearance by the kidneys, with much less accumulation in the liver and other organs
  • To monitor timedependent spectral shifts reflecting surfactant displacement, a programmed sequence of 230 blank-corrected fluorescence spectra were recorded by the NS1 NanoSpectralyzer at 700-ms intervals from a 0.5-ml sample of the Pluronic suspension

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