Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes.

We examined the plasma nerve growth factor level and the distribution ofNGF receptors in peripheral lymphocytes of young sodiers experiencing the thrill of a novice about to make their first parachute jumps

L. Aloe; L. Bracci-Laudiero; E. Alleva; A. Lambiase; A. Micera; P. Tirassa

2006

Scholarcy highlights

  • We examined the plasma nerve growth factor level and the distribution ofNGF receptors in peripheral lymphocytes of young sodiers experiencing the thrill of a novice about to make their first parachute jumps
  • To assess whether any change of NGF levels was associated with biological mediators involved in NGF synthesis and/or release plasma levels of cortisol, adrenocorticotropic hormone, interleukin 1(, and tumor necrosis factor a were evaluated
  • The results showed that the levels of NGF and the expression of nerve growth factor receptor in young soldiers who experienced their firstjump from an aircraft are enhanced both pre- and postjumping and that the increase of NGF precedes the increase of cortisol and ACTH plasma levels
  • To gain more information about the functional role of endogenously released NGF, we studied the distribution of p75LNGFR and lymphocyte-selective markers on peripheral blood mononuclear cells of Control P're-jump Post-jumnp but was not seen in prejump parachutists
  • This observation is consistent with our previous observations showing that the plasma NGF levels in fighting mice was higher in subordinate than in dominant mice
  • The levels of NGF in the bloodstream of parachuting soldiers increased 84% in prejump and 107% in postjump plasma samples
  • It was found that the increase in NGF occurred without parallel increase in cortisol and ACTH, indicating that NGF release is not correlated with these endocrine signals
  • Our previous studies in rodents and the present observations in humans clearly indicate that emotional stress enhances plasma nerve growth factor levels

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