The ornithine decarboxylase gene is a transcriptional target of c-Myc.

We demonstrate that c-Myc is a potent transactivator of ornithine decarboxylase promoter-reporter gene constructs in fibroblasts that requires the CACGTG repeat

C Bello-Fernandez; G Packham; J L Cleveland

2006

Scholarcy highlights

  • The ornithine decarboxylase gene contains a conserved repeat of the Myc binding site, CACGTG, in intron 1
  • We demonstrate that c-Myc is a potent transactivator of ODC promoter-reporter gene constructs in fibroblasts that requires the CACGTG repeat
  • These sites conferred Myc responsiveness on heterologous promoter constructs, suggesting that ODC is regulated by Myc at the level of transcription initiation
  • Analysis of deletion and point mutants of c-myc revealed that domains required for transactivation of the ODC promoter did not include the leucine zipper of the Myc protein
  • This suggests that Myc may interact with transcription factors other than Max to transactivate the ODC gene
  • This suggests that Myc may interact with transcription factors other than Max to transactivate the ornithine decarboxylase gene

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