Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

Our results indicate that a majority of follicular lymphomas have t(14;18) breakpoints on chromosome 18 near a locus that is transcriptionally active in lymphomas carrying the t(14;18) translocation

M L Cleary; J Sklar

2006

Scholarcy highlights

  • The t(14;18)(q32;21) chromosomal translocation characteristic of follicular lymphomas is the most common cytogenetic abnormality known to be associated with any specific type of hematolymphoid malignancy
  • Karyotype analysis was performed on circulating tumor cells of patient JLN with a follicular small-cleaved-cell lymphoma
  • Rearranged immunoglobulin heavy chain genes bands identical to those obtained with the JH probe were seen when we examined JLN
  • Lymphoma DNA with a 0.8-kb enhancer-region probe that contains only DNA 3' to the JH region. This identity suggested that the two rearranged bands were not reciprocal recombination products resulting from a single IGH gene rearrangement
  • The t(14;18) chromosomal translocation is the most common consistent cytogenetic abnormality known among hematolymphoid malignancies
  • One cultured cell line derived from a diffuse undifferentiated lymphoma, another morphologic subtype of B-cell lymphoma, contains the t(14;18) translocation
  • Karyotype data are not available on the tumor samples that we studied, but since cytogenetic studies indicate that almost 90% of follicular lymphomas contain the t(14;18) karyotypic abnormality, most of the 40% that lack DNA rearrangements detectable with our probes probably have breakpoints that occur outside of the cluster region

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