A single 5.8-kilobase species of Ab-MuLV mRNA was detected with as little as 0.25,ug of total cellular RNA applied to the gel
Our present study shows that the human homologues of the onc genes of MC29, Ab-MuLV, Harvey murine sarcoma virus, and SSV are expressed in some or all human hematopoietic cells tested
A parallel study examining human solid tumor cell lines and normal fibroblasts with the same abl probe and the viral onc gene of BALB-MuSV, which is closely related to Harvey-ras, revealed widespread transcription of multiple species of mRNA
These results are consistent with the interpretation that these genes may have an important role in normal cellular functions
It has been shown that a mouse erythroid precursor cell line expressed high levels of a p21 protein assumed to be the product of c-Harvey-ras, suggesting a correspondence of the pathogeneity of v-Harvey-ras with the in vivo tissue specificity for expression of the cellular gene
Our results failed to show a correlation of high-level expression of the onc genes examined with specific types of leukemias
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