In order to examine the effects of antiretroviral therapy on human immunodeficiency virus type 1 transmission, we studied stable HIV-1–discordant couples, who may not be entirely representative of the general population.29
2011
Key concepts
- sexual transmission
- Food and Drug Administration
- antiretroviral therapy
- acquired immunodeficiency syndrome
- human immunodeficiency virus type 1
- Centers for Disease Control and Prevention
- end point
- World Health Organization
- cubic millimeter
- viral replication
- HIV Prevention Trials Network
- Infectious disease
- HIV-1–
- National Institute of Allergy and Infectious Diseases
Scholarcy highlights
- Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 in serodiscordant couples
- Combination antiretroviral therapy decreases the replication of human immunodeficiency virus type 1 and improves the survival of infected persons
- Because the sexual transmission of HIV-1 from infected persons to their partners is strongly correlated with concentrations of HIV-1 in blood and in the genital tract, it has been hypothesized that antiretroviral therapy could reduce sexual transmission of the virus
- Several observational studies have reported decreased acquisition of HIV-1 by sexual partners of patients receiving antiretroviral therapy. These results have been extrapolated to suggest that the use of early antiretroviral therapy could reduce the spread of the virus in a population
- Some ecologic studies have shown a reduction in the incidence of new cases of HIV-1 after expanded use of antiretroviral therapy
- There were 23 deaths during the course of the study, 10 in the early-therapy group and 13 in the delayed-therapy group
- In order to examine the effects of antiretroviral therapy on HIV-1 transmission, we studied stable HIV-1–discordant couples, who may not be entirely representative of the general population
- Several observational studies have reported decreased acquisition of human immunodeficiency virus type 1 by sexual partners of patients receiving antiretroviral therapy. These results have been extrapolated to suggest that the use of early antiretroviral therapy could reduce the spread of the virus in a population. Some ecologic studies have shown a reduction in the incidence of new cases of HIV-1 after expanded use of antiretroviral therapy
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