Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy

The three-drug combination of indinavir, zidovudine, and lamivudine reduced the viral load in serum to less than 500 copies per milliliter for up to one year in more than 80 percent of the human immunodeficiency virus -infected patients we studied, all of whom had prior antiretroviral therapy

Roy M. Gulick

2002

Scholarcy highlights

  • The new protease inhibitors are potent inhibitors of the human immunodeficiency virus, and in combination with other antiretroviral drugs they may be able to cause profound and sustained suppression of HIV replication
  • COMBINATION therapy with two nucleoside analogues is better than monotherapy in reducing levels of human immunodeficiency virus RNA, increasing CD4 cell counts, and preventing the acquired immunodeficiency syndrome and death
  • The HIVprotease inhibitors are a newer class of agents with potent antiretroviral activity
  • Dose-escalation studies showed that monotherapy with indinavir or ritonavir affected HIV RNA levels and CD4 cell counts markedly
  • A recent study showed that a combination of zidovudine, zalcitabine, and saquinavir had more antiretroviral activity than zidovudine combined with either zalcitabine or saquinavir, the treatment effects were relatively small and transient
  • The three-drug combination of indinavir, zidovudine, and lamivudine reduced the viral load in serum to less than 500 copies per milliliter for up to one year in more than 80 percent of the HIV-infected patients we studied, all of whom had prior antiretroviral therapy
  • COMBINATION therapy with two nucleoside analogues is better than monotherapy in reducing levels of human immunodeficiency virus RNA, increasing CD4 cell counts, and preventing the acquired immunodeficiency syndrome and death. The HIVprotease inhibitors are a newer class of agents with potent antiretroviral activity. Early dose-escalation studies showed that monotherapy with indinavir or ritonavir affected HIV RNA levels and CD4 cell counts markedly. These antiretroviral effects were transient in some patients at lower drug doses and were associated with the emergence of drug-resistant virus. A recent study showed that a combination of zidovudine, zalcitabine, and saquinavir had more antiretroviral activity than zidovudine combined with either zalcitabine or saquinavir, the treatment effects were relatively small and transient

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