The Modification of Diet in Renal Disease Study

For reasons that are unknown, chronic kidney failure of diverse causes tends to progress to end-stage renal disease

Saulo Klahr

2010

Scholarcy highlights

  • For reasons that are unknown, chronic kidney failure of diverse causes tends to progress to end-stage renal disease
  • Several hypotheses have been advanced to explain the mechanisms by which renal insufficiency progresses,123 but none have been definitely established
  • Studies in animals and clinical trials in humans567 with chronic renal disease suggest that the dietary restriction of protein and phosphorus may slow the rate of progression
  • The trials of low-protein, low-phosphorus diets in humans have generally been deficient with respect to experimental design
  • The deficiencies include the lack of proper randomization procedures, absence or inappropriateness of control populations, use of

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