Immune Interferon in the Circulation of Patients with Autoimmune Disease

We found immune interferon in the serums of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma and Sjögren's syndrome

John J. Hooks; Haralampos M. Moutsopoulos; Shirley A. Geis; Neil I. Stahl; John L. Decker; Abner Louis Notkins

2010

Scholarcy highlights

  • The observation that type II, or immune, interferon could be produced by peripheral-blood leukocytes in vitro on an immune-specific basis suggested that it might be produced in vivo in various autoimmune disorders
  • We found immune interferon in the serums of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma and Sjögren's syndrome
  • Serial serum samples showed a good correlation between interferon titers and disease activity
  • It is possible that the production of interferon may contribute to immunologic aberrations in autoimmune diseases and protect the already compromised host from viral infections.
  • From the Laboratory of Oral Medicine, National Institute of Dental Research, and the Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD

Need more features? Save interactive summary cards to your Scholarcy Library.