Thyroid Autoregulation: Evidence for an Action of Iodoarachidonates and Iodide at the Cell Membrane Level

The present results demonstrate that the inhibition exerted by iodoarachidonates, on AIB and DOG uptake, in calf thyroid slices, is organ-specific, dose-dependent and may be produced, at least in part, by an impairment of Na-K-ATPase activity, which is involved in the energy contribution for this metabolic transport across the cell membrane

L. Krawiec; H. Chester; Laura Bocanera; Laura Pregliasco; G. Juvenal; M. Pisarev

2008

Scholarcy highlights

  • Iodolipids are the possible mediators of excess iodide in thyroid autoregulation
  • Previous work from our laboratory has shown that 14-iodo-15-hydroxy-5,8,11 eicosatrienoic acid and its omega lactone mimic the inhibitory action of excess iodide upon several parameters of thyroid metabolism
  • The present experiments were performed in order to study the mechanism of the inhibitory effect of I-HO-A and IL-w on 2-deoxy-D-glucose and aminoisobutyric acid uptake by calf slices
  • The transport of DOG was inhibited by both compounds: I-HO-A caused a 62% decrease, while IL-w produced a 64% inhibition; and mM methimazole failed to relieve their action
  • TSH produced a 74% increase in the enzyme activity which was significantly blocked by KI, I-HO-A and IL-w
  • The present results demonstrate that the inhibition exerted by iodoarachidonates, on AIB and DOG uptake, in calf thyroid slices, is organ-specific, dose-dependent and may be produced, at least in part, by an impairment of Na-K-ATPase activity, which is involved in the energy contribution for this metabolic transport across the cell membrane

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