Prognostic factors in diffuse malignant pleural mesothelioma: effects of pretreatment clinical and laboratory characteristics

In this study we aimed to investigate the e¡ects of various pretreatment clinical and laboratory characteristics on the survival of patients with Di¡use malignant pleural mesothelioma

M. METINTAS

2002

Scholarcy highlights

  • Di¡use malignant pleural mesothelioma is a highly lethal neoplasm
  • In this study we aimed to investigate the e¡ects of various pretreatment clinical and laboratory characteristics on the survival of patients with DMPM
  • The following pretreatment characteristics were evaluated for prognostic importance: age, gender, Karnofsky performance score, asbestos exposure, presence of chest pain, presence of dyspnoea, weight loss, symptom duration, smoking history, primary location of disease, platelet count, haemoglobin, white blood cell count, serum lactate dehydrogenase, extent of disease, histopathologic subtype
  • We investigated the e¡ects of various pretreatment characteristics on the survival of patients with DMPM
  • The younger mean age in our series may be due to the beginning of asbestos exposure at birth
  • To date the overall response rate has been low and the median survival time is not long enough to justify chemotherapy schedules, some studies indicate that mesothelioma may not be totally chemotherapy-resistant and that some chemotherapeutics are moderately e¡ective and tolerable, especially for responsive patients
  • We determined a relation between male gender, smoking history and poor prognosis in univariate analysis but not multivariate

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