Regeneration and functional recovery in the upper extremity of rats after various types of nerve injuries

We found no indications of articular contractures or automutilations after injuries to nerves from the brachial plexus, suggesting ß 2003 Peripheral Nerve Society, Inc

Eleana N. Bontioti

2003

Scholarcy highlights

  • Sciatic nerve injury in rats is a dominant model for studies of peripheral nerve regeneration
  • A conditioning lesion, i.e., an initial lesion of the same nerve preceding a test injury by a few days, of both motor/sensory fibers led to a quicker functional recovery
  • The present study was aimed at delineating basic regenerative measures like functional recovery, axonal outgrowth, and cell body response, following various injuries to the nerves of the upper extremity in the rat including crush injury, transection and repair or graft interposition, and different types of conditioning lesions
  • Median and ulnar nerves – crush lesion In animals subjected to a crush lesion on both the median and the ulnar nerves just above the elbow, the toe spread of the first and fourth and second and third digits decreased to 67 Æ 3 and 54 Æ 4%, respectively, at 14 days as compared with their preoperative values
  • Median and ulnar nerves – proximal versus distal crush When the crush lesion was induced at a more proximal site, just after the nerves had emerged from the brachial plexus, the distance between the first and fourth and second and third toe decreased to 52 Æ 3% at 6 days as compared with 67 Æ 3% with a more distal lesion of those two nerves
  • The degree of misdirected axonal outgrowth of regenerating nerve fibers by neurofilament immunocytochemistry correlated with the recovery of function of the pawprints
  • Injuries to the nerves of the upper extremity exhibited the classical conditioning lesions effect, i.e., an increased regenerative capability following a test crush lesion if the nerve had been injured previously, as seen in the sciatic nerve model1990b;

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