Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy

Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12–14 weeks' gestation

Victor J. Pop; Johannes L. Kuijpens; Anneloes L. van Baar; Gerda Verkerk; Maarten M. van Son; Jan J. de Vijlder; Thomas Vulsma; Wilmar M. Wiersinga; Hemmo A. Drexhage; Huib L. Vader

2002

Scholarcy highlights

  • Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12–14 weeks' gestation
  • Overt maternal hypothyroidism as seen in severe iodine-deficient areas is associated with severely impaired neurological development of the offspring
  • Neurodevelopment was assessed at 10 months of age in a cohort of 220 healthy children, born after uncomplicated pregnancies and deliveries, using the Bayley Scales of Infant Development
  • Maternal gestational free T4 concentration was defined as an independent parameter for child development

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