Thyroid hormones are important for embryonic to larval transitory phase in zebrafish

We investigated the role of thyroid hormone in this important embryonic to larval transitory phase

Yi-Wen Liu; Woon-Khiong Chan

2003

Scholarcy highlights

  • Like many other teleost species, the development and differentiation of many major organs continue unabated into the yolk-sac larval stage before culminating in a free-swimming larva capable of exogenous feeding
  • We investigated the role of thyroid hormone in this important embryonic to larval transitory phase
  • The developmental arrest is lethal, and treated larvae do not survive beyond 7 day postfertilization, but can be completely rescued by the presence of 10 nM T4
  • We propose that the embryonic to larval transitory phase in many teleost species is characterized by its dependency on the timely synthesis of TH and the concomitant autoinductive increase in TRĪ² mRNA levels

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