Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2

These findings suggest that platelet-activating factor increases i partly by discharge of internal Ca2+, but mainly by stimulated influx

T J Hallam; A Sanchez; T J Rink

2015

Scholarcy highlights

  • In the presence of 1 mM external calcium, platelet-activating factor raisedi 8-10-fold in a few seconds to peak near 1 microM.i declined over several minutes towards the basal level
  • In the absence of external calcium there was a much smaller increase ini of similar pattern. These findings suggest that PAF increasesi partly by discharge of internal Ca2+, but mainly by stimulated influx
  • The possible involvement of products of phosphoinositide breakdown is discussed

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