Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

The Prxs exhibit a number of intriguing properties that distinguish them from conventional antioxidants, including a susceptibility to inactivation by hyperoxidation in the presence of excess peroxide and the ability to form complex oligomeric structures

Andrew G. Cox; Christine C. Winterbourn; Mark B. Hampton

2009

Scholarcy highlights

  • The Prxs exhibit a number of intriguing properties that distinguish them from conventional antioxidants, including a susceptibility to inactivation by hyperoxidation in the presence of excess peroxide and the ability to form complex oligomeric structures
  • Multicellular organisms express several different Prxs that can be categorized by their subcellular distribution
  • Prx 3 and Prx 5 are targeted to the mitochondrial matrix
  • Mitochondria are a major source of hydrogen peroxide, and this oxidant is implicated in the damage associated with aging and a number of pathologies
  • A simple kinetic competition analysis estimates that Prx 3 will be the target for up to 90% of hydrogen peroxide generated in the matrix
  • Mitochondrial Prxs have the potential to play a major role in mitochondrial redox signalling, but the extent of this role and the mechanisms involved are currently unclear

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