Antigenicity of some new synthetic polypeptides and polypeptidyl gelatins

In this paper we report the contribution of different amino acids present in the immunogenically important areas of the molecule to the antigenic response

S Fuchs; M Sela

2015

Scholarcy highlights

  • The attachment of peptides of methionine, of leucine and glutamic acid, and of lysine and glutamic acid to gelatin resulted in enhancement of antigenicity, whereas the attachment of copolypeptides of glutamic acid and phenylalanine, histidine, leucine or lysine to the synthetic multichain poly-DL-alanine converted it into immunogens
  • The enhancement of gelatin antigenicity upon attachment of methionine peptides would point to the contribution of this amino acid towards immunogenicity, even though its peptides did not convert multichain polyalanine into an immunogen
  • The peptides attached were those of L-methionine as well as copolypeptides of L-glutamic acid and L-phenylalanine, L-histidine, L-leucine or L-lysine
  • The attachment of peptides of methionine, of leucine and glutamic acid, and of lysine and gluitamic acid to gelatin resulted in enhancement of antigenicity, whereas the attachment of copolypeptides of glutamic acid and phenylalanine, histidine, leucine or lysine to multichain polyalanine converted it into immunogens
  • The attachment of peptides of methionine to multichain polyalanine did not affect its lack of antigenicity
  • 2. The attachment of peptides of methionine, of leucine and glutamic acid, and of lysine and gluitamic acid to gelatin resulted in enhancement of antigenicity, whereas the attachment of copolypeptides of glutamic acid and phenylalanine, histidine, leucine or lysine to multichain polyalanine converted it into immunogens

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