NaOTs-promoted transition metal-free C–N bond cleavage to form C–X (X = N, O, S) bonds

This study provides a novel solution with mild conditions and a simple procedure for transformation of multiple amides

Yuqi Zhang; Xiaojing Ye; Sicheng Liu; Wei Chen; Irfan Majeed; Tingting Liu; Yulin Zhu; Zhuo Zeng

2021

Scholarcy highlights

  • Multifunctional transformation of amide C–N bond cleavage is reported
  • The protocol applies to benzamide, thioamide, alcohols, and mercaptan under similar reaction conditions catalyzed by NaOTs
  • This study provides a novel solution with mild conditions and a simple procedure for transformation of multiple amides
  • This article is part of the themed collection: Synthetic methodology in OBC

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