Aptamer-based strategies for recognizing adenine, adenosine, ATP and related compounds

This review summarizes the efforts for the selection of RNA and DNA aptamers for adenine derivatives, and we pay particular attention to the specificity of binding

Yuqing Li; Juewen Liu

2020

Scholarcy highlights

  • Adenine is a key nucleobase, adenosine is an endogenous regulator of the immune system, while adenosine triphosphate is the energy source of many biological reactions. Selective detection of these molecules is useful for understanding biological processes, biochemical reactions and signaling
  • This review summarizes the efforts for the selection of RNA and DNA aptamers for adenine derivatives, and we pay particular attention to the specificity of binding
  • Most of the work in the field was performed on the classic DNA aptamer for adenosine and ATP reported by the Szostak group
  • We critically review the limit of the reported aptamers and important problems in the field, which can give future research opportunities

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