Simultaneous detection of paracetamol and 4-aminophenol at nanomolar levels using biocompatible cysteine-substituted phthalocyanine

Extension of the conjugation and biocompatibility of the phthalocyanine molecule is expected to improve its stability and interaction with bio-molecules without any fouling

Manjunatha Palanna; Imadadulla Mohammed; Shambhulinga Aralekallu; Manjunatha Nemakal; Lokesh Koodlur Sannegowda

2019

Key concepts

Scholarcy highlights

  • Extension of the conjugation and biocompatibility of the phthalocyanine molecule is expected to improve its stability and interaction with bio-molecules without any fouling
  • A novel thio-bridged cysteine ligand and its respective cobalt phthalocyanine complex have been synthesized. These molecules were characterized with TGA and FT-IR, UV-Vis, mass and NMR spectroscopy techniques
  • The spectral data reveal the successful formation of the desired compounds with high purity
  • The CoTATPAPc molecule was uniformly coated on the electrode, and the designed GCE/CoTATPAPc displayed remarkable electrocatalytic efficiency for the simultaneous sensing of paracetamol and 4-aminophenol
  • The sensitivity value of GCE/CoTATPAPc was extremely high, indicating the superior and rapid response of the designed sensor. This sensor showed great reproducibility, repeatability, high selectivity and stability for detecting PA as well as 4-AP even when interfering compounds were present in high concentrations
  • The developed sensor was successfully evaluated for the testing of commercial samples
  • Simultaneous detection of paracetamol and 4-aminophenol at nanomolar levels using biocompatible cysteine-substituted phthalocyanine

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