Characterization of tumor-targeting Ag2S quantum dots for cancer imaging and therapy in vivo

Nanomedicine platforms that have the potential to simultaneously provide the function of molecular imaging and therapeutic treatment in one system are beneficial to address the challenges of cancer heterogeneity and adaptive resistance

Haiyan Chen

2014

Scholarcy highlights

  • Cyclic RGD peptide, a less-expensive active tumor targeting tri-peptide, and doxorubicin, a widely used chemotherapeutic drug, were covalently attached to Ag2S quantum dots to form the nano-conjugates Ag2S-DOX-cRGD
  • Nanomedicine platforms that have the potential to simultaneously provide the function of molecular imaging and therapeutic treatment in one system are beneficial to address the challenges of cancer heterogeneity and adaptive resistance
  • The optical characterization of Ag2S-DOX-Cyclic RGD peptide manifested the maintenance of quantum dots fluorescence, which suggested the potential of Ag2S for monitoring intracellular and systemic drug distribution
  • These results indicated a promising future for the utilization of Ag2S QDs as a kind of multi-functional nano platform to achieve imaging-visible nano-therapeutics
  • Reproduced material should be attributed as follows: For reproduction of material from NJC: - Reproduced by permission of The Royal Society of Chemistry on behalf of the Centre National de la Recherche Scientifique and the RSC

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