Electrochemiluminescence resonance energy transfer between graphene quantum dots and gold nanoparticles for DNA damage detection

Bright blue luminescent graphene quantum dots with major graphitic structured nanocrystals and a photoluminescence quantum yield of 15.5% were synthesized and used to monitor DNA damage

Qian Lu; Wei Wei; Zhenxian Zhou; Zhixin Zhou; Yuanjian Zhang; Songqin Liu

2014

Scholarcy highlights

  • Bright blue luminescent graphene quantum dots with major graphitic structured nanocrystals and a photoluminescence quantum yield of 15.5% were synthesized and used to monitor DNA damage
  • The GQDs were prepared by ultraviolet irradiation without using a chemical agent
  • The as-prepared GQDs showed excitation-dependent PL and stable electrochemiluminescence behaviors
  • The ECL signal of the GQDs could be quenched by non-covalent binding of the AuNPs-ssDNA to the GQDs, due to the occurrence of an electrochemiluminescence resonance energy transfer between the GQDs and the AuNPs
  • The resultant ECL sensor could be used for DNA damage detection based on its different bonding ability to damaged target p53 ssDNA and cp53 ssDNA linked AuNPs

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