Protein–water electrostatics and principles of bioenergetics

We show here that standard considerations based on rules of Gibbs thermodynamics are not sufficient, and the dynamics of the protein and the protein–water interface need to be involved

David N. LeBard

2010

Scholarcy highlights

  • Despite its diversity, life universally relies on a simple basic mechanism of energy transfer in its energy chains—hopping electron transport between centers of electron localization on hydrated proteins and redoxcofactors
  • We show here that standard considerations based on rules of Gibbs thermodynamics are not sufficient, and the dynamics of the protein and the protein–water interface need to be involved
  • Numerical simulations show that the statistics of the electrostatic potential produced by hydration water are strongly non-Gaussian, with the breadth of the electrostatic noise far exceeding the expectations of the linear response
  • Reproduced material should be attributed as follows: For reproduction of material from NJC: - Reproduced by permission of The Royal Society of Chemistry on behalf of the Centre National de la Recherche Scientifique and the RSC
  • For reproduction of material from PPS: - Reproduced by permission of The Royal Society of Chemistry on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
  • For reproduction of material from all other RSC journals: - Reproduced by permission of The Royal Society of Chemistry

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