Clickable polyglycerol hyperbranched polymers and their application to gold nanoparticles and acid-labile nanocarriers

We reported a method for the synthesis of degradable dendrimers and hydrogels utilizing 1,3,5-triazaadamantane monomers.15

Andrew Zill

2010

Scholarcy highlights

  • Polyglycerol dendrimers and hyperbranched polyglycerols have a number of attractive properties that have led to their use in a broad range of applications from drug delivery devices to catalysis to diversity platforms for synthesis.1 Arguably, the most important property is the biocompatibility afforded by the water-soluble, highly branched polyether–polyol structure
  • Two routes to alkyne-functionalized HPG are outlined in Fig. 1
  • An alternative synthesis uses propargyl alcohol as an alkyne source allowing the HPG to be prepared in a single step
  • We have outlined a simple procedure for the synthesis of alkyne functionalized HPG. These polymers facilitated the preparation of potential biological imaging agents such as monofunctionalized fluorescein and biotin HPG, the stabilization of gold nanoparticles, and the synthesis of unimolecular acid-labile micelles
  • We are continuing to investigate the use of these polymers as a method for the functionalization and stabilization of nanoparticles, as well as stabilizing agents for water-soluble fluorescent dyes

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