The results show that DNA strand cleavage efficiency depends on the concentration of complex 1, the pH value of the buffer, and the duration of the photolysis of complex 1
2009
The water-soluble Roussin's red ester acting as a potential photochemical NO-delivery agent: Photolysis reactions, DNA cleavage and anticancer activity
Key concepts
Scholarcy highlights
- The water-soluble Roussin's red ester, a potential photochemical prodrug of an NO precursor, was synthesized from the reaction of HSCH2CH2P(O)(CH2OH) and
- NO was released with a stoichiometry ratio Δ/Δ = 3.6 ± 0.2 when complex 1 was exposed to UV in deaerated aqueous phosphate buffer solution
- The results show that DNA strand cleavage efficiency depends on the concentration of complex 1, the pH value of the buffer, and the duration of the photolysis of complex 1
- Reproduced material should be attributed as follows: For reproduction of material from NJC: - Reproduced by permission of The Royal Society of Chemistry on behalf of the Centre National de la Recherche Scientifique and the RSC
- For reproduction of material from PPS: - Reproduced by permission of The Royal Society of Chemistry on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
- For reproduction of material from all other RSC journals: - Reproduced by permission of The Royal Society of Chemistry
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