The water-soluble Roussin's red ester acting as a potential photochemical NO-delivery agent: Photolysis reactions, DNA cleavage and anticancer activity

The results show that DNA strand cleavage efficiency depends on the concentration of complex 1, the pH value of the buffer, and the duration of the photolysis of complex 1

Han-Hun Chang

2009

Scholarcy highlights

  • The water-soluble Roussin's red ester, a potential photochemical prodrug of an NO precursor, was synthesized from the reaction of HSCH2CH2P(O)(CH2OH) and
  • NO was released with a stoichiometry ratio Δ/Δ = 3.6 ± 0.2 when complex 1 was exposed to UV in deaerated aqueous phosphate buffer solution
  • The results show that DNA strand cleavage efficiency depends on the concentration of complex 1, the pH value of the buffer, and the duration of the photolysis of complex 1
  • Reproduced material should be attributed as follows: For reproduction of material from NJC: - Reproduced by permission of The Royal Society of Chemistry on behalf of the Centre National de la Recherche Scientifique and the RSC
  • For reproduction of material from PPS: - Reproduced by permission of The Royal Society of Chemistry on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
  • For reproduction of material from all other RSC journals: - Reproduced by permission of The Royal Society of Chemistry

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