NO-Group transfer (transnitrosation) between S-nitrosothiols and thiols. Part 2

The kinetics of NO-group transfer have been measured for the reaction between a nitrosothiol and nine thiols, mostly based on the cysteine structure

D. Jonathan Barnett; Ana Rios; D. Lyn H. Williams

2004

Scholarcy highlights

  • The kinetics of NO-group transfer have been measured for the reaction between a nitrosothiol and nine thiols, mostly based on the cysteine structure
  • Reaction occurs via the thiolate anion as shown by the pH-rate constant profile, and a full kinetic analysis for the reactions of two thiols is quantitatively in agreement with this mechanism
  • Variation of the nitrosothiol structure for reaction with N-acetylcysteine shows that electron-withdrawing substituents in the nitrosothiol promote reaction; there is a similarity with the corresponding reactions of alkyl nitrites

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