Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines

The results indicated that derivatives showed a noteworthy in vitro anti-in ammatory activity as they potently suppressed the COX-2 activity

Haroon ur Rashid; Marco Antonio Utrera Martines; Adriana Pereira Duarte; Juliana Jorge; Shagufta Rasool; Riaz Muhammad; Nasir Ahmad; Muhammad Naveed Umar


Scholarcy highlights

  • The word in ammation is derived from the Latin “ amma” meaning ame
  • The results indicated that both monoaryl – as well as bisarylsubstituted 2-aminopyrimidines potently inhibited the PGE2 generation regardless of the length of C-5 substituents in polysubstituted pyrimidines
  • The results revealed that the suppression of inducible nitric oxide synthase by few of the target derivatives was competitive with the L-arginine and reversible
  • The results suggested that this type of pyrimidine derivatives might behave as nuclear factor kappa-light-chainenhancer of activated B cells-deoxyribonucleic acid and activator protein 1-DNA binding inhibitors that can prohibit free AP-1 and NF-kB from binding to DNA.124
  • Pyrimidines represent a group of aromatic heterocyclic compounds, enclosing two nitrogen atoms at positions-1 and -3 of the main six-member ring
  • The potential use of various pyrimidine derivatives as anti-in ammatory agents is expected owing to their high potency and minimum toxicity
  • Pyridodipyrimidines carrying electronreleasing groups display superior anti-in ammatory activities than pyrimidines of the same type with electron-withdrawing groups

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