The aqueous extract ofOlea europaealeaves protects from haematotoxicity and kidney damage induced by diclofenac in Swiss albino mice

This study evaluated the antioxidant activities, and the beneficial effects of the aqueous extract of “Sahli” Olea europaea leaves on diclofenac-induced haematotoxicity and nephrotoxicity in Swiss albino mice

Raouya Soussi; Najla Hfaiedh; Mohsen Sakly; Khémais Ben Rhouma

2019

Scholarcy highlights

  • Non-steroidal anti-in ammatory drugs are a diverse group of chemical agents with similar biological capabilities, regularly used for pain relief and the treatment of many in ammatory diseases. Diclofenac belongs to the family of NSAID, which is considered as one of the most commonly used painkillers.3This product has some potent biological activities that affect cellular function in every organ, and it has been shown that the efficacy of DF in reducing pain and in ammation is associated with various side reactions mostly affecting the gastrointestinal system, kidneys and risk of heart attack. nephrotoxicity is one of the most common kidney problems, which occurs when the body is exposed to a drug or toxin. In addition, the long-term therapeutic consumption of DF is reportedly associated with some adverse effects on haematological, biochemical and oxidative parameters as well as chronic nephrotoxicity
  • DF, a non-steroidal anti-in ammatory drug that belongs to the acetic acid group, was purchased from the Central Pharmacy of Gafsa Tunisia, which was produced by the “DAR ESSAYDALI LABORATORY” Tunisia to be dissolved in saline solution for injection
  • Exposure of the mice to DF for ve consecutive days caused a signi cant reduction in red blood cells, white blood cells, haemoglobin, haematocrit, mean corpuscular volume and mean cell haemoglobin concentration values, while a signi cant increase in platelet number as compared to the control group was observed
  • In the) group, these parameters were restored to normal levels
  • Our results revealed that the aqueous extract of Olea europaea leaves was found to exhibit strong antioxidant activities based on numerous in vitro and in vivo assays
  • Due to its richness in polyphenol and avonoid components, pre-treatment with EOLS in DF-injected mice improved their haematological and biochemical parameters, as well as the histopathological changes in their kidney tissues, and minimised the adverse effect of oxidative stress induced by this drug in mice tissues

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