Coordination chemistry of pyrazine derivatives analogues of PZA: design, synthesis, characterization and biological activity

Due to the low number of scienti c publications and information on analogues of PZA, it is believed that the results of our research shown in this paper will be an original and signi cant contribution to the development of the eld

MaƂgorzata Ogryzek


Scholarcy highlights

  • In the past, transition metals and medicinal applications were thought to be mutually exclusive
  • The results of elemental analysis and analytical data of the examined coordination compounds suggest that the metal to ligand ratio of the complexes is 1 : 2 stoichiometry of the typeCl for PTCA and PAOX andCl for ABMAP, 1 : 1 stoichiometry of the typeCl for DPP, respectively, where py stands for bidentate pyrazine derivatives
  • The present study showed that coordination by the nitrogen donor atoms in the bidentate ligands could successfully stabilize the higher oxidation states of a transition metal
  • The synthesis of Ru(III) with PTCA, PAOX, DPP and ABMAP has already been described in this paper
  • The coordination number of the Ru(III) complexes was 6, and on the basis of this coordination number, the structures proposed for the complexes were shown in Fig. 4
  • The results of semi-empirical calculations showed that each Ru(III) complex with selected pyrazine derivative had octahedral geometry, which was in conformity with the data obtained from spectroscopic and analytical experiments
  • X-ray crystallographic investigations, which might con rm the proposed structures, could not be

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