Application of paramagnetic graphene quantum dots as a platform for simultaneous dual-modality bioimaging and tumor-targeted drug delivery

This paper reports the development of a multifunctional nanocarrier platform consisting of paramagnetic graphene quantum dots, folate, and doxorubicin for simultaneous fluorescence and magnetic resonance imaging, and cancer treatment

Chun-Lin Huang; Chih-Ching Huang; Fu-Der Mai; Chia-Liang Yen; Shin-Hwa Tzing; Hsiao-Ting Hsieh; Yong-Chien Ling; Jia-Yaw Chang

2014

Scholarcy highlights

  • We report the development of a multifunctional nanocarrier consisting of paramagnetic graphene quantum dots, folate, and doxorubicin, used as delivery vehicles, a targeting ligand, and a chemotherapeutic drug, respectively
  • An in vitro cell viability assay and in vivo evaluation of toxicity to the embryonic development of zebrafish showed that these folate–GdGQDs exhibited negligible cytotoxicity and excellent biocompatibility within the given range of concentrations
  • Strong therapeutic activity was achieved by loading Dox onto the surfaces of folate–GdGQDs through π–π stacking and hydrophobic interactions, leading to the formation of folate–GdGQD/Dox multifunctional nanocarriers
  • 80% of the loaded Dox was released from the folate–GdGQD/Dox nanocarriers under mild acidic conditions, whereas only 20% of Dox was released at pH 7.0 after 48 h
  • The combined flow cytometry analysis and confocal laser scanning microscopic observation showed that these nanocarriers were efficiently taken up by the cancer cells overexpressing folate receptors. These results suggested that the multifunctional nanocarriers could be used as promising targeted drug delivery vehicles for the diagnosis and image-guided chemotherapy of various cancers
  • This article is part of the themed collections: JMC B Top Picks web collection: Seeing the unseen: Advances in bioimaging and biosensors and JMC B Top Picks collection: Recent advances in drug delivery

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