Carbon-nanotube-modified glassy carbon electrodes for amplified label-free electrochemical detection of DNA hybridization

The preparation and attractive performance of carbon-nanotube modified glassy-carbon electrodes for improved detection of purines, nucleic acids, and DNA hybridization are described

Joseph Wang; Abdel-Nasser Kawde; Mustafa Musameh

2003

Scholarcy highlights

  • The preparation and attractive performance of carbon-nanotube modified glassy-carbon electrodes for improved detection of purines, nucleic acids, and DNA hybridization are described
  • The advantages of CNT/GC electrodes are illustrated from comparison to the common unmodified glassy carbon, carbon paste and graphite pencil electrodes
  • The dramatic amplification of the guanine signal has been combined with a label-free electrical detection of DNA hybridization
  • Factors influencing the enhancement of the guanine signal are assessed and optimized
  • The performance characteristics of the amplified label-free electrochemical detection of DNA hybridization are reported in connection to measurements of nucleic-acid segments related to the breast-cancer BRCA1 gene

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