Cancer mortality in a cohort of asbestos textile workers

The standardized mortality ratios of mesothelioma was 2780, and when we considered selected time-related covariates together in a model, latency was the main determinant of mesothelioma risk

E Pira

2005

Scholarcy highlights

  • A cohort of 889 men and 1077 women employed for at least 1 month between 1946 and 1984 by a former Italian leading asbestos company, characterised by extremely heavy exposures often for short durations, was followed up to 1996, for a total of 53 024 person-years of observation
  • Employment data were obtained from factory personnel records, while vital status and causes of death were ascertained through municipality registers and local health units
  • Chrysotile fibres are considered less carcinogenic than amphiboles and it has been estimated that cohorts exposed to amosite and crocidolite experience an excess of lung cancer in the exposure specific risk of around 5% per ff ml1 year, while the corresponding risk for chrysotile alone is between 0.1 and 0.5%
  • The standardized mortality ratios of mesothelioma was 2780, and when we considered selected time-related covariates together in a model, latency was the main determinant of mesothelioma risk
  • The latency period between first asbestos exposure and occurrence of mesothelioma is seldom less than 10 years, while we found that two male subjects had died from pleural cancer only 6 years after first employment
  • Among the strengths of the study are the high number of women included, the originality of the cohort, which included subjects exposed to very high doses of asbestos fibres, and the long followup that allowed to adequately evaluate risk of mesothelioma, that is, a cancer with a long latency period between first asbestos exposure and cancer death
  • Hodgson JT, Darnton A The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure

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