BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration

We found that BIRC5 was significantly correlated with multiple immune cells infiltrates in a variety of tumors

Linlong Xu; Wenpeng Yu; Han Xiao; Kang Lin

2021

Scholarcy highlights

  • BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation
  • BIRC5 expression was relatively high in advanced tumor stages in KIRC, KIRP, LIHC, LUAD and UCEC, and relatively low in advanced tumor stages in STAD
  • In KIRC, STAD, and UCEC, BIRC5 expression was higher in advanced tumor stages
  • Su et al investigated the role of BIRC5 in hepatocellular carcinoma and reported that octamer-binding transcription factor 44 enhanced the expression of BIRC5 via cyclin D1
  • High expression of BIRC5 is associated with poor prognosis in patients with hepatocellular and pancreatic cancer, lung cancer, renal papillary cell carcinoma, renal clear cell carcinoma, endometrial carcinoma, and sarcoma
  • Our finding that BIRC5 expression in KIRP, LIHC, LUAD, and PAAD was significantly correlated with infiltration of multiple immune cells indicate that BIRC5 may be a potential immunotherapeutic target in these tumors
  • We found that BIRC5 expression levels correlated with methyltransferase expression levels in different types of tumors, and the association between immune checkpoints and BIRC5 in cancer shows its potential as a therapeutic target
  • Having explored the relationship between BIRC5 and the tumor microenvironment and immune cell infiltration, we wanted to investigate the mechanism by which they are linked or associated with immune checkpoint genes

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