The human connectome in Alzheimer disease — relationship to biomarkers and genetics

We review studies of the associations between connectome changes and amyloid-β and tau pathologies as well as molecular genetics in different subtypes and stages of Alzheimer disease

Meichen Yu; Olaf Sporns; Andrew J. Saykin

2021

Scholarcy highlights

  • The pathology of Alzheimer disease damages structural and functional brain networks, resulting in cognitive impairment
  • Amyloid-β pathology is associated with decreased hub connectivity in the default-mode network during the preclinical stage of Alzheimer disease and the association extends to other brain networks as the disease progresses
  • Spatial gene expression profiles might contribute to the relationships between the patterns of Aβ and tau accumulation and patterns of structural and functional connectome changes in AD
  • Computational modelling studies will be important for understanding the role of the connectome in relation to progression of Aβ, tau and other pathogenic features of AD
  • This article was one of the first linking Aβ accumulation and tau spreading with brain-wide gene expression in the human AD
  • A symmetric matrix, in which each element is computed by estimating the Euclidean distance between the centre coordinates of two brain regions

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