Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation

We report that a small adaptor protein, SH3BGRL, is upregulated in the majority of breast cancer patients, especially elevated in those with metastatic relapse, indicating it as a marker for the poor prognosis of breast cancer

Shaoyang Zhang; Xuemin Guo; Xiufeng Liu; Zhixiong Zhong; Shulan Yang; Haihe Wang

2021

Scholarcy highlights

  • Metastatic recurrence is still a major challenge in breast cancer treatment, but the underlying mechanisms remain unclear
  • We report that a small adaptor protein, SH3BGRL, is upregulated in the majority of breast cancer patients, especially elevated in those with metastatic relapse, indicating it as a marker for the poor prognosis of breast cancer
  • Clinical analysis validates that SH3BGRL expression is negatively correlated with profilin 1 and PTEN levels, but positively to the activations of AKT, NF-kB, and WNT signaling pathways in breast patient tissues
  • Our results suggest that SH3BGRL is a valuable prognostic factor and a potential therapeutic target for preventing breast cancer progression and metastasis

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